{"id":81295,"date":"2026-04-15T11:15:55","date_gmt":"2026-04-15T09:15:55","guid":{"rendered":"https:\/\/cri1149.fr\/publication\/basophils-drive-the-resolution-and-promote-wound-healing-in-adult-and-aged-mice\/"},"modified":"2026-04-22T15:22:23","modified_gmt":"2026-04-22T13:22:23","slug":"basophils-drive-the-resolution-and-promote-wound-healing-in-adult-and-aged-mice","status":"publish","type":"publication","link":"https:\/\/cri1149-dev.mlcom-dev.net\/en\/publication\/basophils-drive-the-resolution-and-promote-wound-healing-in-adult-and-aged-mice\/","title":{"rendered":"Basophils drive the resolution and promote wound healing in adult and aged mice."},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

Abstract :<\/h2>\n\n\n\n

An active resolution is critical to control the duration of inflammation and limit its pathological consequences. Defects in resolution during wound healing allow the emergence of chronic wounds, a common complication in the elderly. Here, we show that basophils accumulate in perivascular areas at the periphery of mouse skin wounds for at least 3 wk, during both the inflammation and resolution phases of wound healing. Depletion of basophils induces an increased secretion of inflammatory molecules, accumulation and activation of pro-inflammatory leukocytes, and delays the wound healing response. Basophils particularly promote epidermal differentiation towards homeostasis. These properties are particularly driven by basophil-derived IL-4. Unexpectedly, aged mice basophils more potently infiltrate skin wounds to promote inflammation resolution. Thus, basophils are pro-resolution cells during an essential biological process such as skin wound healing. Unraveling basophil pro-resolution properties may reveal new strategies to fight chronic wounds in the elderly.<\/p>\n","protected":false},"featured_media":81344,"template":"","meta":{"_acf_changed":true},"category_publication":[403,404],"class_list":["post-81295","publication","type-publication","status-publish","has-post-thumbnail","hentry","category_publication-publication-sur-la-banniere","category_publication-publications-marquantes"],"acf":{"numero_de_publication":"J Exp Med.","date_de_publication":"20260504","numero_doi":"10.1084\/jem.20240764","equipe":[334],"auteurs-liste":[{"texte_libre":false,"auteur-lien":13036,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Victoria Peter"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Chaimae Saji"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Claire Dupont"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Mathilde Lavernhe"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Suoqin Jin"},{"texte_libre":false,"auteur-lien":16167,"auteur-text":""},{"texte_libre":false,"auteur-lien":13078,"auteur-text":""},{"texte_libre":false,"auteur-lien":73974,"auteur-text":""},{"texte_libre":false,"auteur-lien":62876,"auteur-text":""},{"texte_libre":false,"auteur-lien":13209,"auteur-text":""},{"texte_libre":false,"auteur-lien":14854,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Xing Dai"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Kensuke Miyake"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Hajime Karasuyama"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Jean X Jiang"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Karmella Naidoo"},{"texte_libre":false,"auteur-lien":13030,"auteur-text":""},{"texte_libre":false,"auteur-lien":13037,"auteur-text":""},{"texte_libre":false,"auteur-lien":13121,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Graham Le Gros"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Agn\u00e8s Coste"},{"texte_libre":false,"auteur-lien":13051,"auteur-text":""},{"texte_libre":false,"auteur-lien":14855,"auteur-text":""}],"auteurs-manuel":"","liens_externes":[{"url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/41885768\/"}],"liens":null,"paragraphe":"","paragraphe_en":"","documents":null},"yoast_head":"\nBasophils drive the resolution and promote wound healing in adult and aged mice. - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Basophils drive the resolution and promote wound healing in adult and aged mice. - CRI\" \/>\n<meta property=\"og:description\" content=\"Abstract : An active resolution is critical to control the duration of inflammation and limit its pathological consequences. 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